Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.78 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.68 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.67 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.66 |
| ▸ | GUSB | P08236 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.63 |
| ▸ | FAAH | O00519 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608032 | 0.88 | SMPD1 (1.00) | SMPD1NR4A2MAOBNR1H4GPR132 | |
| SCHEMBL16015339 | 0.88 | MEN1 (0.71) | SMPD1NR4A2ALDH1A1NPC1RAB9A | |
| SCHEMBL31148956 | 0.88 | ALDH1A1 (0.69) | SMPD1NR4A2ALDH1A1NPC1RAB9A | |
| SCHEMBL13702365 | 0.87 | SMPD1 (0.76) | SMPD1NR4A2RAB9AMAOBNR1H4 | |
| SCHEMBL21616251 | 0.85 | SMPD1 (0.74) | SMPD1NR4A2SMN1; SMN2MAOBNR1H4 | |
| SCHEMBL3442550 | 0.85 | PTPN1 (0.75) | SMPD1NR4A2MAOBNR1H4GPR132 | |
| SCHEMBL32665557 | 0.85 | SPHK2 (0.83) | SMPD1NR4A2NPC1RAB9AMAOB | |
| SCHEMBL17894403 | 0.85 | SMPD1 (0.69) | SMPD1NR4A2RAB9AMAOBNR1H4 | |
| SCHEMBL1387246 | 0.84 | NR4A2 (0.77) | SMPD1NR4A2MAOBNR1H4PTPN1 | |
| SCHEMBL13702183 | 0.84 | GPR132 (0.73) | SMPD1NR4A2MAOBNR1H4GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107236106-A | The aromatic series terminal hydroxy group chain extender of the key containing acylhydrazone, selfreparing polyurethane and preparation method thereof | 青岛科技大学 | 2017-10-10 | — | — | CN | claimed |
| WO-2022180080-A1 | ANTI-PROLIFERATIVE AGENTS | FIRST HEALTH PHARMACEUTICALS B.V. (NL) | 2022-09-01 | — | — | WO | disclosed |
| EP-4050002-A1 | ANTI-PROLIFERATIVE AGENTS | First Health Pharmaceuticals B.V. (NL) | 2022-08-31 | — | — | EP | disclosed |
| CN-107236106-B | Aromatic hydroxyl-terminated chain extender containing acylhydrazone bond, self-repairing polyurethane and preparation method of chain extender | 青岛科技大学 | 2020-01-07 | — | — | CN | disclosed |
| CN-107236106-A | The aromatic series terminal hydroxy group chain extender of the key containing acylhydrazone, selfreparing polyurethane and preparation method thereof | 青岛科技大学 | 2017-10-10 | — | — | CN | disclosed |
| US-20110081297-A1 | Novel Substituted Pyrazoles, 1,2,4-Oxadiazoles, and 1,3,4-Oxadiazoles | MERCK & CO. INC. | 2011-04-07 | — | — | US | disclosed |
| US-20110081297-A1 | Novel Substituted Pyrazoles, 1,2,4-Oxadiazoles, and 1,3,4-Oxadiazoles | MERCK & CO. INC. | 2011-04-07 | — | — | US | disclosed |
| WO-2009146343-A1 | NOVEL SUBSTITUTED PYRAZOLES, 1,2,4-OXADIAZOLES, AND 1,3,4-OXADIAZOLES | MERCK & CO., INC. (US) | 2009-12-03 | — | — | WO | disclosed |
| CN-1950374-A | Tetraazabenzo[e]azulene derivatives and analogs thereof | PFIZER (US) | 2007-04-18 | — | — | CN | disclosed |
| EP-1079821-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1079821-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059570-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110081297-A1 | Novel Substituted Pyrazoles, 1,2,4-Oxadiazoles, and 1,3,4-Oxadiazoles | APP, PSEN1, BACE1 | SMPD1 2045/4885NR4A2 541/4885ALDH1A1 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.