Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 5/20 | 0.84 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.84 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.84 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.84 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.84 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.84 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437376 | 1.00 | CHRNA3 (0.84) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7405817 | 0.98 | CHRNB2 (0.82) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7365529 | 0.91 | CHRNB2 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL905222 | 0.91 | CHRNB2 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7840224 | 0.90 | CHRNB2 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7828342 | 0.90 | CHRNB2 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7414235 | 0.84 | CHRNA3 (0.70) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7407318 | 0.84 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7911829 | 0.84 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7911837 | 0.84 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | claimed |
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |