Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346576 | 0.92 | KDM4E (0.66) | KDM4EALDH1A1HRH3MAPTPOLB | |
| SCHEMBL7409733 | 0.90 | S1PR5 (0.63) | KDM4EALDH1A1HRH3S1PR5KMT2A | |
| SCHEMBL7406632 | 0.81 | S1PR5 (0.62) | ALDH1A1HRH3SMN1; SMN2S1PR5LTA4H | |
| SCHEMBL7355105 | 0.81 | L3MBTL1 (0.51) | KDM4EALDH1A1HRH3TDP1SMN1; SMN2 | |
| SCHEMBL7347681 | 0.80 | ALDH1A1 (0.64) | KDM4EALDH1A1HRH3KCNH2MAPT | |
| SCHEMBL7467785 | 0.78 | HRH3 (0.76) | KDM4EALDH1A1HRH3KCNH2MAPT | |
| SCHEMBL7345881 | 0.76 | S1PR5 (0.60) | ALDH1A1HRH3KCNH2MAPTS1PR5 | |
| SCHEMBL7415473 | 0.75 | L3MBTL1 (0.67) | KDM4EALDH1A1HRH3MAPTSMN1; SMN2 | |
| SCHEMBL6988354 | 0.75 | KDM4E (0.74) | KDM4EALDH1A1HRH3MAPTPOLB | |
| SCHEMBL22895271 | 0.74 | KDM4E (0.77) | KDM4EALDH1A1HRH3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054858-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042436-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-08-26 | — | — | WO | disclosed |