Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LIG1 | P18858 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646422 | 0.84 | GUSB (0.44) | KDM4EBRD4TSHRHPGDHSD17B10 | |
| SCHEMBL149188 | 0.81 | KMT2A (0.48) | KDM4EBRD4HPGDHSD17B10CASP1 | |
| SCHEMBL11625477 | 0.81 | PARP1 (0.42) | KDM4ELIG1PARP1TSHRGAA | |
| SCHEMBL7645372 | 0.81 | KMT2A (0.53) | KDM4EPARP1BRD4TSHRHPGD | |
| SCHEMBL8069138 | 0.81 | HTT (0.44) | KDM4EPARP1BRD4GCGRMAPK14 | |
| SCHEMBL7646746 | 0.80 | PDE5A (0.41) | BRD4 | |
| SCHEMBL7462690 | 0.77 | ALDH1A1 (0.41) | KDM4ELIG1TSHRGAAGCGR | |
| SCHEMBL3798396 | 0.75 | KDM4E (0.71) | KDM4ELIG1PARP1TSHRGAA | |
| SCHEMBL11711629 | 0.72 | GAA (0.45) | LIG1TSHRGAA | |
| SCHEMBL10051830 | 0.71 | IKBKB (0.50) | KDM4ELIG1PARP1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347027-B1 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE FRENCH LAB (GB) | 1994-08-03 | — | — | EP | claimed |
| EP-0347027-A2 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | claimed |
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999059584-A1 | COMBINATION OF PHENTOLAMINE AND CYCLIC GMP PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | SCHERING CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
| EP-0347027-B1 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE FRENCH LAB (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5254571-A | Bronchodilators, antiallergens | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0347027-A2 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |