Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.39 |
| ▸ | PLAU | P00749 | 3/20 | 0.39 |
| ▸ | PLAT | P00750 | 3/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645797 | 0.86 | XDH (0.44) | HTTXDHSIRT2BRD4F2 | |
| SCHEMBL7646422 | 0.86 | GUSB (0.44) | BRD4PDE5AALDH1A1KDM4EMAPT | |
| SCHEMBL149188 | 0.84 | KMT2A (0.48) | HTTBRD4PDE5APDE4APDE4B | |
| SCHEMBL7645372 | 0.83 | KMT2A (0.53) | HTTBRD4PDE5APDE4APDE4B | |
| SCHEMBL11624915 | 0.81 | PDE5A (0.46) | HTTXDHSIRT2PDE5APDE4A | |
| SCHEMBL7411482 | 0.81 | KDM4E (0.44) | BRD4GCGRMAPK14KDM4EPARP1 | |
| SCHEMBL7646746 | 0.80 | PDE5A (0.41) | SIRT2BRD4PDE5APDE4APDE4B | |
| SCHEMBL8069141 | 0.78 | GAA (0.51) | HTTXDHSIRT2ALDH1A1KDM4E | |
| SCHEMBL27725562 | 0.77 | HTT (0.54) | HTTXDHSIRT2PDE5APDE4A | |
| SCHEMBL7647019 | 0.77 | XDH (0.45) | XDHPDE5APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347027-B1 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE FRENCH LAB (GB) | 1994-08-03 | — | — | EP | claimed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5254571-A | Bronchodilators, antiallergens | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1993-10-19 | — | — | US | disclosed |