Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526774 | 0.86 | HTR2B (0.72) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL7420874 | 0.85 | MAPT (0.59) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL9049984 | 0.83 | MAPT (0.49) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL8529863 | 0.83 | HTR2C (0.56) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL7474827 | 0.77 | HTR2C (0.58) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL9051003 | 0.75 | HTT (0.46) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL29462322 | 0.72 | HTR2B (0.87) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL4855474 | 0.71 | HTT (0.75) | MAPTHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7423705 | 0.70 | HTR2C (0.76) | HTR2BCYP1A2CYP3A4MAPTBLM | |
| SCHEMBL5053541 | 0.70 | HTT (0.73) | CYP1A2MAPTHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |