Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049984 | 0.83 | MAPT (0.49) | HTTMEN1KMT2ASMN1; SMN2GALR3 | |
| SCHEMBL9049771 | 0.82 | CYP1A2 (0.54) | HTTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7474827 | 0.81 | HTR2C (0.58) | HTTMEN1KMT2ASMN1; SMN2GALR3 | |
| SCHEMBL9050471 | 0.77 | HTR2C (0.47) | MEN1KMT2ASMN1; SMN2RAB9AUSP2 | |
| SCHEMBL7411485 | 0.75 | HTR2B (0.53) | HTTMEN1KMT2ASMN1; SMN2GALR3 | |
| SCHEMBL8529863 | 0.75 | HTR2C (0.56) | HTTMEN1KMT2ASMN1; SMN2GALR3 | |
| SCHEMBL8526774 | 0.74 | HTR2B (0.72) | HTTMEN1KMT2ARAB9AUSP2 | |
| SCHEMBL9050180 | 0.72 | HTR2C (0.64) | HTR2AHTR2C | |
| SCHEMBL7420874 | 0.72 | MAPT (0.59) | HTTMEN1KMT2ASMN1; SMN2GALR3 | |
| SCHEMBL6589470 | 0.70 | IGF1R (0.62) | HTTMEN1KMT2ASMN1; SMN2GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691973-A1 | THIENO-INDOLE DERIVATIVES AS 5HT2c AND 5HT2b ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022871-A1 | THIENO-INDOLE DERIVATIVES AS 5HT2c AND 5HT2b ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-10-13 | — | — | WO | disclosed |