Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 12/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | HTR2C | P28335 | 13/20 | 0.57 |
| ▸ | HTR2A | P28223 | 10/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462322 | 0.87 | HTR2B (0.87) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL7411485 | 0.86 | HTR2B (0.53) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL1157493 | 0.84 | HTR2B (1.00) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL29390781 | 0.84 | HTR2B (1.00) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL9049984 | 0.82 | MAPT (0.49) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL7420874 | 0.82 | MAPT (0.59) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL8529863 | 0.81 | HTR2C (0.56) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL8526276 | 0.74 | HTR2C (0.76) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL7474827 | 0.74 | HTR2C (0.58) | HTR2BCYP1A2CYP3A4MAPTNFKB1 | |
| SCHEMBL9051003 | 0.74 | HTT (0.46) | HTR2BCYP1A2CYP3A4MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | claimed |
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |