Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNG | P07510 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRND | Q07001 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7465133 | 0.80 | CHRNA3 (0.49) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| Citric Acid SCHEMBL7415645 | 0.79 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| Citric Acid SCHEMBL7403694 | 0.79 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| Citric Acid SCHEMBL7670396 | 0.78 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| Citric Acid SCHEMBL7407586 | 0.78 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| Citric Acid SCHEMBL7411438 | 0.77 | SLC13A5 (0.37) | CHRNB2CHRNA4KDM4E | |
| Citric Acid SCHEMBL7408885 | 0.77 | CHRNB2 (0.44) | CHRNB2CHRNA4 | |
| SCHEMBL7465136 | 0.77 | CHRNA3 (0.46) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| Citric Acid SCHEMBL7403867 | 0.76 | CHRNB2 (0.43) | CHRNB2CHRNA4 | |
| Citric Acid SCHEMBL6585267 | 0.74 | CHRNB4 (0.48) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |