Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605356 | 1.00 | MAPT (0.47) | MAPTSMN1; SMN2HTTUSP2ALOX15 | |
| SCHEMBL30688429 | 0.78 | POLB (0.49) | MAPTSMN1; SMN2POLBGAANPC1 | |
| SCHEMBL7407275 | 0.77 | POLB (0.40) | MAPTSMN1; SMN2LMNAPOLBNPC1 | |
| SCHEMBL7410328 | 0.77 | POLB (0.40) | MAPTSMN1; SMN2LMNAPOLBNPC1 | |
| SCHEMBL7605352 | 0.75 | POLB (0.39) | MAPTSMN1; SMN2LMNAPOLBNPC1 | |
| SCHEMBL2071309 | 0.75 | CYP2C19 (0.46) | SMN1; SMN2USP2LMNAPOLBNPC1 | |
| SCHEMBL4215659 | 0.73 | GLS (0.48) | MAPTSMN1; SMN2USP2LMNAPOLB | |
| SCHEMBL27624468 | 0.73 | POLB (0.55) | MAPTSMN1; SMN2ALOX15LMNAPOLB | |
| SCHEMBL3942724 | 0.72 | CYP2C19 (0.43) | SMN1; SMN2HTTUSP2LMNAPOLB | |
| SCHEMBL11635124 | 0.72 | CYP2C19 (0.46) | MAPTSMN1; SMN2LMNAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937042-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017643-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |