Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402269 | 0.93 | SIGMAR1 (0.54) | SIGMAR1S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL7412187 | 0.79 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1BCHE | |
| SCHEMBL7398354 | 0.78 | S1PR5 (0.44) | SIGMAR1S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL27268607 | 0.76 | SIGMAR1 (0.56) | SIGMAR1MEN1KMT2ABCHE | |
| SCHEMBL24131518 | 0.76 | MEN1 (0.44) | SIGMAR1S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL22440366 | 0.76 | MEN1 (0.44) | SIGMAR1S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL7538307 | 0.73 | BCHE (0.47) | SIGMAR1S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL13766174 | 0.73 | S1PR5 (0.56) | S1PR5S1PR1S1PR3S1PR4BCHE | |
| SCHEMBL14554075 | 0.73 | S1PR5 (0.56) | S1PR5S1PR1S1PR3S1PR4BCHE | |
| SCHEMBL7512062 | 0.71 | S1PR5 (0.57) | S1PR5S1PR1S1PR3S1PR4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003740-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS | Abbott Laboratories (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999006397-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1999-02-11 | — | — | WO | disclosed |
| EP-0885215-A1 | NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997030045-A1 | NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1997-08-21 | — | — | WO | disclosed |