Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 13/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13766174 | 0.78 | S1PR5 (0.56) | S1PR5S1PR1S1PR3S1PR4SMN1; SMN2 | |
| SCHEMBL14554075 | 0.78 | S1PR5 (0.56) | S1PR5S1PR1S1PR3S1PR4SMN1; SMN2 | |
| SCHEMBL7402269 | 0.77 | SIGMAR1 (0.54) | S1PR5S1PR1S1PR3S1PR4SMN1; SMN2 | |
| SCHEMBL13772703 | 0.76 | GNAI3 (0.59) | S1PR5S1PR1S1PR3S1PR4MAPT | |
| SCHEMBL4005891 | 0.76 | GNAI3 (0.59) | S1PR5S1PR1S1PR3S1PR4MAPT | |
| SCHEMBL7508959 | 0.75 | S1PR5 (0.56) | S1PR5S1PR1S1PR3S1PR4SMN1; SMN2 | |
| SCHEMBL7522334 | 0.75 | S1PR5 (0.48) | S1PR5S1PR1S1PR3S1PR4SMN1; SMN2 | |
| SCHEMBL8784826 | 0.75 | S1PR5 (0.41) | S1PR5S1PR1S1PR3S1PR4SMN1; SMN2 | |
| SCHEMBL9494162 | 0.74 | KCNH2 (0.64) | S1PR5S1PR1S1PR3S1PR4KCNH2 | |
| SCHEMBL9493891 | 0.74 | KCNH2 (0.64) | S1PR5S1PR1S1PR3S1PR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003740-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS | Abbott Laboratories (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999006397-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1999-02-11 | — | — | WO | disclosed |