Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.37 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10741271 | 0.90 | DYRK1A (0.40) | TNFDYRK1AP2RX3CASP3TP53 | |
| SCHEMBL10739220 | 0.89 | DYRK1A (0.39) | TNFDYRK1AP2RX3CASP3TP53 | |
| SCHEMBL7412224 | 0.83 | TNF (0.47) | TNFDYRK1AP2RX3CASP3GAA | |
| SCHEMBL10741229 | 0.83 | P2RX3 (0.41) | DYRK1AP2RX3CASP3 | |
| SCHEMBL7409269 | 0.83 | P2RX3 (0.40) | DYRK1AP2RX3CASP3KDM4EPOLB | |
| SCHEMBL7412075 | 0.79 | DYRK1A (0.47) | TNFDYRK1AP2RX3CASP3 | |
| SCHEMBL10747062 | 0.76 | P2RX3 (0.37) | TNFDYRK1AP2RX3KDM4EPOLB | |
| SCHEMBL10740769 | 0.75 | CASP3 (0.38) | DYRK1AP2RX3CASP3KDM4EGAA | |
| Bromide SCHEMBL7409238 | 0.73 | TNF (0.44) | TNFDYRK1AP2RX3GAA | |
| SCHEMBL10976729 | 0.72 | P2RX3 (0.42) | DYRK1AP2RX3CASP3TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |