SCHEMBL7412252

SCHEMBL7412252

O=C(Cc1ncc[nH]c1=O)OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.54
L3MBTL1 Q9Y468 3/20 0.54
MAPK1 P28482 1/20 0.54
ENPP2 Q13822 1/20 0.44
KMT2A Q03164 3/20 0.43
MEN1 O00255 1/20 0.43
GLA P06280 1/20 0.42
ROCK2 O75116 1/20 0.41
TSHR P16473 1/20 0.40
CASP3 P42574 1/20 0.40
RAB9A P51151 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
POLB P06746 2/20 0.40
CDC25B P30305 1/20 0.40
TDP1 Q9NUW8 2/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A3 Q01959 1/20 0.40
MMP1 P03956 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7447820 0.79 SMN1; SMN2 (0.49) ALDH1A1MAPK1KMT2ATSHRTDP1
SCHEMBL7618263 0.75 TAAR1 (0.58) ALDH1A1KMT2AGLATSHRLMNA
SCHEMBL7876115 0.73 SMN1; SMN2 (0.50) ALDH1A1KMT2AMEN1GLATSHR
SCHEMBL432658 0.73 TDP1 (0.53) ALDH1A1L3MBTL1MAPK1KMT2ATSHR
SCHEMBL361779 0.72 ALDH1A1 (1.00) ALDH1A1L3MBTL1MAPK1ENPP2KMT2A
SCHEMBL29225340 0.71 ALDH1A1 (0.64) ALDH1A1L3MBTL1MAPK1ENPP2KMT2A
SCHEMBL5917187 0.71 ALDH1A1 (0.64) ALDH1A1L3MBTL1MAPK1KMT2ATSHR
SCHEMBL13939871 0.71 DAO (0.45) RAB9A
SCHEMBL6784181 0.70 ALDH1A1 (0.96) ALDH1A1L3MBTL1MAPK1ENPP2KMT2A
SCHEMBL2652042 0.70 ALDH1A1 (0.79) ALDH1A1L3MBTL1MAPK1ENPP2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017393-A4 PYRAZINONE THROMBIN INHIBITORS MERCK & CO INC (US) 2002-01-23 EP disclosed
EP-0934305-A4 INTEGRIN ANTAGONISTS MERCK & CO INC (US) 2001-04-11 EP disclosed
EP-1086122-A1 PYRAZINONE PROTEASE INHIBITORS Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) 2001-03-28 EP disclosed
EP-1017393-A1 PYRAZINONE THROMBIN INHIBITORS Merck & Co., Inc. (US) 2000-07-12 EP disclosed
WO-1999064446-A1 PYRAZINONE PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1999-12-16 WO disclosed
EP-0934305-A1 INTEGRIN ANTAGONISTS Merck & Co., Inc. (US) 1999-08-11 EP disclosed
WO-1999011267-A1 PYRAZINONE THROMBIN INHIBITORS MERCK & CO., INC. (US) 1999-03-11 WO disclosed
EP-0900207-A1 PYRAZINONE THROMBIN INHIBITORS Merck & Co., Inc. (US) 1999-03-10 EP disclosed
WO-1998008840-A1 INTEGRIN ANTAGONISTS MERCK & CO., INC. (US) 1998-03-05 WO disclosed
WO-1997040024-A1 PYRAZINONE THROMBIN INHIBITORS MERCK & CO., INC. (US) 1997-10-30 WO disclosed