SCHEMBL432658

SCHEMBL432658

O=C(OCc1ccccc1)c1ncc[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.53
KMT2A Q03164 3/20 0.53
SLC6A2 P23975 1/20 0.53
SLC6A3 Q01959 1/20 0.53
POLB P06746 1/20 0.51
LMNA P02545 2/20 0.50
MMP2 P08253 2/20 0.49
MMP9 P14780 2/20 0.49
MMP12 P39900 2/20 0.49
ALDH1A1 P00352 4/20 0.49
L3MBTL1 Q9Y468 3/20 0.48
TSHR P16473 2/20 0.48
CASP3 P42574 1/20 0.48
RAB9A P51151 1/20 0.48
SENP8 Q96LD8 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
TAAR1 Q96RJ0 1/20 0.47
MMP1 P03956 1/20 0.47
EGLN1 Q9GZT9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2167257 0.94 POLB (0.50) TDP1KMT2ASLC6A2SLC6A3POLB
SCHEMBL4014439 0.88 KMT2A (0.48) TDP1KMT2ASLC6A2SLC6A3POLB
SCHEMBL28413301 0.88 KMT2A (0.53) TDP1KMT2ASLC6A2SLC6A3POLB
SCHEMBL11181967 0.80 CASP3 (0.58) TDP1KMT2APOLBLMNAMMP2
SCHEMBL5918034 0.79 RXFP1 (0.61) KMT2APOLBLMNAALDH1A1TSHR
SCHEMBL2421709 0.79 KMT2A (0.42) KMT2APOLBL3MBTL1TSHRRAB9A
SCHEMBL24844709 0.78 MMP12 (0.51) TDP1KMT2AMMP2MMP9MMP12
SCHEMBL11411711 0.77 RAB9A (0.41) KMT2AALDH1A1L3MBTL1TSHRRAB9A
SCHEMBL28415823 0.77 NPC1 (0.42) KMT2ASLC6A2SLC6A3POLBLMNA
SCHEMBL11836426 0.76 KMT2A (0.47) TDP1KMT2AALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107148453-B Photocurable composition 思美定株式会社 2021-08-17 CN disclosed
CN-108431157-B Bonding method using photocurable adhesive 思美定株式会社 2021-02-05 CN disclosed
US-10844251-B2 Pressure-sensitive adhesive CEMEDINE CO., LTD. (JP) 2020-11-24 US disclosed
CN-105392845-B Photocurable composition 思美定株式会社 2020-10-20 CN disclosed
CN-107532061-B Pressure-sensitive adhesive 思美定株式会社 2020-03-03 CN disclosed
EP-3081612-B1 PHOTOCURABLE COMPOSITION HAVING ADHESIVE PROPERTIES CEMEDINE CO LTD (JP) 2018-11-14 EP disclosed
US-20180298239-A1 PRESSURE-SENSITIVE ADHESIVE CEMEDINE CO., LTD. (JP) 2018-10-18 US disclosed
US-10029989-B2 Imidazole derivatives HOFFMANN-LA ROCHE INC. (US) 2018-07-24 US disclosed
US-20180118692-A1 IMIDAZOLE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2018-05-03 US disclosed
EP-3287501-A1 PRESSURE-SENSITIVE ADHESIVE Cemedine Co., Ltd. (JP) 2018-02-28 EP disclosed
WO-1995017403-A1 GUANINE SYNTHONS FOR PEPTIDE NUCLEIC ACID SYNTHESIS AND METHOD FOR PRODUCTION PERSEPTIVE BIOSYSTEMS, INC. (US) 1995-06-29 WO disclosed
EP-0633935-A1 STABILITY-ENHANCED VARIANTS OF PARATHYROID HORMONE Allelix Biopharmaceuticals Inc. (CA) 1995-01-18 EP disclosed
EP-0048614-B1 1-N-ACYLATED AND 1-N-ALKYLATED DERIVATIVES OF 4-0-SUBSTITUTED -2-DEOXYSTREPTAMINE AMINOGLYCOSIDES ELI LILLY AND COMPANY (US) 1985-03-20 EP disclosed
EP-0048613-B1 4-0-SUBSTITUTED -2-DEOXYSTREPTAMINE AMINOGLYCOSIDE DERIVATIVES, THEIR PREPARATION AND FORMULATIONS CONTAINING THEM ELI LILLY AND COMPANY (US) 1985-01-23 EP disclosed
US-4468513-A 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides ELI LILLY AND COMPANY (US) 1984-08-28 US disclosed
US-4468512-A 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides ELI LILLY AND COMPANY (US) 1984-08-28 US disclosed
US-4424344-A 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process ELI LILLY AND COMPANY (US) 1984-01-03 US disclosed
US-4424345-A 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process ELI LILLY AND COMPANY (US) 1984-01-03 US disclosed
EP-0048613-A1 4-0-Substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them ELI LILLY AND COMPANY (US) 1982-03-31 EP disclosed
EP-0048614-A1 1-N-acylated and 1-N-alkylated derivatives of 4-0-substituted -2-deoxystreptamine aminoglycosides ELI LILLY AND COMPANY (US) 1982-03-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180118692-A1 IMIDAZOLE DERIVATIVES DRD3, GABRR3, DRD4 TDP1 2555/4885KMT2A 2209/4885SLC6A2 906/4885
US-10029989-B2 Imidazole derivatives DRD3, GABRR3, DRD4 TDP1 2555/4885KMT2A 2209/4885SLC6A2 906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.