Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | GALR3 | O60755 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE4A | P27815 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470727 | 0.81 | HPGD (0.73) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL11011884 | 0.80 | KDM4E (0.63) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL8210361 | 0.79 | KDM4E (0.75) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL9587750 | 0.78 | KDM4E (0.73) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL10891425 | 0.78 | KDM4E (0.73) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL7407595 | 0.78 | KDM4E (0.73) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL5460125 | 0.78 | KDM4E (1.00) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL11118460 | 0.77 | PGR (0.49) | HPGDKDM4EALDH1A1GAACYP2C19 | |
| SCHEMBL11011880 | 0.77 | HPGD (0.67) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL4342180 | 0.76 | ESR2 (0.56) | ALDH1A1GAAHSD17B10PGRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | claimed |
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |