Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 5/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979449 | 0.79 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL4018759 | 0.76 | GRIN2B (0.61) | GRIN2BGRIN1TDP1LMNASMN1; SMN2 | |
| SCHEMBL7016188 | 0.73 | GRIN2B (0.57) | GRIN2BGRIN1TDP1LMNASMN1; SMN2 | |
| SCHEMBL7412370 | 0.70 | HPGD (0.54) | GRIN2BGRIN1TDP1LMNASMN1; SMN2 | |
| SCHEMBL2782306 | 0.70 | GRIN2B (0.54) | GRIN2BGRIN1LMNASMN1; SMN2 | |
| SCHEMBL5695116 | 0.68 | IDO1 (0.57) | GRIN2BGRIN1LMNASMN1; SMN2 | |
| SCHEMBL9317358 | 0.68 | ALDH1A1 (0.53) | GRIN2BGRIN1TDP1L3MBTL1LMNA | |
| SCHEMBL25798810 | 0.67 | PDE10A (0.59) | GRIN2BGRIN1 | |
| SCHEMBL103278 | 0.67 | GRIN1 (0.59) | GRIN2BGRIN1TDP1LMNASMN1; SMN2 | |
| SCHEMBL7035626 | 0.67 | GRIN1 (0.59) | GRIN2BGRIN1TDP1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002544162-A | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-1178792-A1 | ARYL AMIDINES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2002-02-13 | — | — | EP | claimed |
| US-6319944-B1 | NMDA NR2B ANTAGONISTS; NEUROLOGICAL AND NEURODEGENERATIVE DISEASES INCLUDING PAIN, (AND IN PARTICULAR NEUROPATHIC PAIN), EPILEPSY, STROKE, ANXIETY, CEREBRAL ISCHEMIA, MUSCULAR SPASMS, ALZHEIMER'S, HUNTINGTON'S AND PARKINSON'S DISEASES | MERCK & CO., INC. | 2001-11-20 | — | — | US | claimed |
| WO-2000067751-A1 | ARYL AMIDINES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2000-11-16 | — | — | WO | claimed |
| US-6319944-B1 | NMDA NR2B ANTAGONISTS; NEUROLOGICAL AND NEURODEGENERATIVE DISEASES INCLUDING PAIN, (AND IN PARTICULAR NEUROPATHIC PAIN), EPILEPSY, STROKE, ANXIETY, CEREBRAL ISCHEMIA, MUSCULAR SPASMS, ALZHEIMER'S, HUNTINGTON'S AND PARKINSON'S DISEASES | MERCK & CO., INC. | 2001-11-20 | — | — | US | disclosed |