Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | GLA | P06280 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21385305 | 0.85 | KDM4E (0.60) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL26661256 | 0.83 | KDM4E (0.69) | KDM4EGAAALDH1A1MAPTNPC1 | |
| 7-Methoxychromone SCHEMBL1854902 | 0.80 | KDM4E (1.00) | KDM4EGAAALDH1A1MAPTNPC1 | |
| 7-Methoxychromone SCHEMBL31260290 | 0.80 | KDM4E (1.00) | KDM4EGAAALDH1A1MAPTNPC1 | |
| SCHEMBL15495628 | 0.79 | KDM4E (0.64) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL6826684 | 0.78 | KDM4E (0.71) | KDM4EFTOROCK2ROCK1CA12 | |
| SCHEMBL11179993 | 0.77 | KDM4E (0.65) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL17708884 | 0.76 | KDM4E (0.64) | KDM4EFTOROCK2ROCK1CA12 | |
| SCHEMBL5502413 | 0.76 | KDM4E (0.59) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL743266 | 0.76 | MAPT (0.55) | KDM4EGLAGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |