Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 7/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 9/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7412254 | 0.96 | AVPR1B (0.48) | AVPR1BAVPR1APLGITGB3ITGA2B | |
| SCHEMBL7414099 | 0.88 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL7418575 | 0.88 | ITGB3 (0.55) | ITGB3ITGA2B | |
| SCHEMBL7412260 | 0.88 | AVPR1A (0.45) | AVPR1BAVPR1APLG | |
| SCHEMBL7463784 | 0.84 | ITGB3 (0.48) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7417558 | 0.84 | ITGB3 (0.49) | ITGB3ITGA2BF2 | |
| SCHEMBL7693853 | 0.84 | ITGB3 (0.51) | ITGB3ITGA2B | |
| SCHEMBL7695352 | 0.84 | ITGB3 (0.49) | ITGB3ITGA2BF2 | |
| Trifluoroacetic Acid SCHEMBL7422529 | 0.84 | ITGB3 (0.51) | ITGB3ITGA2B | |
| SCHEMBL7421961 | 0.83 | ITGB3 (0.53) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |