Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18320847 | 0.84 | AOC3 (0.50) | TAAR1AOC3L3MBTL1CASR | |
| SCHEMBL18403140 | 0.84 | AOC3 (0.50) | TAAR1AOC3L3MBTL1CASR | |
| SCHEMBL27536288 | 0.83 | AOC3 (0.49) | TAAR1AOC3L3MBTL1CASRMAPK1 | |
| SCHEMBL413321 | 0.82 | TAAR1 (0.53) | TAAR1AOC3L3MBTL1CASRALDH1A1 | |
| SCHEMBL410128 | 0.82 | TAAR1 (0.53) | TAAR1AOC3L3MBTL1CASRALDH1A1 | |
| SCHEMBL2176341 | 0.82 | AOC3 (0.47) | TAAR1AOC3L3MBTL1CASRALDH1A1 | |
| SCHEMBL16871235 | 0.82 | AOC3 (0.47) | TAAR1AOC3L3MBTL1CASRALDH1A1 | |
| SCHEMBL10245271 | 0.81 | AOC3 (0.48) | TAAR1AOC3L3MBTL1CASR | |
| SCHEMBL9212842 | 0.81 | AOC3 (0.51) | TAAR1AOC3L3MBTL1CASRALDH1A1 | |
| SCHEMBL11081355 | 0.80 | AOC3 (0.54) | TAAR1AOC3L3MBTL1CASRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358973-B1 | FOR THERAPY OF ALLERGIC OR INFLAMMATORY DISEASE | ZAMBON GROUP S.P.A. (IT) | 2002-03-19 | — | — | US | disclosed |
| EP-1121353-A1 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021947-A1 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-04-20 | — | — | WO | disclosed |