Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407267 | 0.88 | NR2E1 (0.58) | NR2E1CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL7412946 | 0.86 | NR2E1 (0.57) | NR2E1CHRNA7HSD17B10 | |
| SCHEMBL7409548 | 0.85 | NR2E1 (0.56) | NR2E1CHRNA7HTR2AHTR2C | |
| SCHEMBL7409746 | 0.84 | NR2E1 (0.55) | NR2E1CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL7412109 | 0.84 | NR2E1 (0.55) | NR2E1CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL7408311 | 0.82 | HTR7 (0.53) | NR2E1CHRNA7DRD2DRD1DRD5 | |
| SCHEMBL25424716 | 0.81 | NR2E1 (0.54) | NR2E1CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL25423066 | 0.81 | NR2E1 (0.54) | NR2E1CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL25424582 | 0.81 | NR2E1 (0.54) | NR2E1CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL7408196 | 0.74 | RB1 (0.50) | NR2E1CHRNA7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4257952-A | PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES | STERLING DRUG INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4172834-A | ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS | STERLING DRUG INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4062864-A | ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3959309-A | ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1976-05-25 | — | — | US | disclosed |