SCHEMBL7412947

SCHEMBL7412947

CC(=O)OC(C)COC(=O)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.57
BCL9 O00512 1/20 0.48
CTNNB1 P35222 1/20 0.48
GAA P10253 2/20 0.47
MAPT P10636 4/20 0.44
MGLL Q99685 2/20 0.43
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 2/20 0.41
POLB P06746 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAOB P27338 1/20 0.41
PKM P14618 1/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
ADRB2 P07550 1/20 0.41
ADRB1 P08588 1/20 0.41
ADRB3 P13945 1/20 0.41
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27355874 0.92 HTR2A (0.60) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL8916739 0.90 HTR2A (0.54) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL2597348 0.88 HTR2A (0.64) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL763026 0.85 HTR2A (0.64) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL9510108 0.83 HSD17B10 (0.42) HTR2AGAAMAPTKMT2APOLB
SCHEMBL7411825 0.82 HTR2A (0.61) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL21097206 0.82 HTR2A (0.61) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL12355356 0.82 HTR2A (0.61) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL2233659 0.81 HTR2A (0.52) HTR2ABCL9CTNNB1GAAMAPT
SCHEMBL29654784 0.80 HTR2A (0.52) HTR2ABCL9CTNNB1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950057-B1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LAB (US) 2002-11-13 EP disclosed
US-6403575-B1 ANTI-INFLAMMATORIES ABBOTT LABORATORIES 2002-06-11 US disclosed
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
US-6133253-A NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES ABBOTT LABORATORIES (US) 2000-10-17 US disclosed
EP-0950057-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS Abbott Laboratories (US) 1999-10-20 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed
WO-1998025920-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LABORATORIES (US) 1998-06-18 WO disclosed