Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18173283 | 0.86 | NR1H2 (0.43) | HTR4WNT1GSK3BDYRK1APLA2G10 | |
| SCHEMBL24709214 | 0.82 | HTR4 (0.40) | HTR4FAAHWNT1GSK3BDYRK1A | |
| SCHEMBL4700650 | 0.81 | HTR4 (0.41) | HTR4WNT1GSK3BDYRK1APLA2G10 | |
| SCHEMBL6217337 | 0.81 | HTR4 (0.41) | HTR4WNT1GSK3BDYRK1APLA2G10 | |
| SCHEMBL27060441 | 0.81 | GPR119 (0.39) | HTR4GPR119FAAHWNT1GSK3B | |
| SCHEMBL24709213 | 0.80 | HTR4 (0.41) | HTR4WNT1GSK3BDYRK1APLA2G10 | |
| SCHEMBL13698802 | 0.79 | SMN1; SMN2 (0.41) | HTR4WNT1GSK3BDYRK1APLA2G10 | |
| SCHEMBL572705 | 0.79 | CHRM2 (0.41) | HTR4WNT1GSK3BDYRK1APLA2G10 | |
| SCHEMBL560636 | 0.78 | GPR119 (0.55) | GPR119FAAHNR1H2 | |
| SCHEMBL3470166 | 0.78 | PLA2G10 (0.41) | HTR4WNT1GSK3BDYRK1APLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |