Benzoic Acid

Benzoic Acid

SCHEMBL7413231

CCc1ccc(OC[C@@H]2CCN2)cn1.O=C(O)c1ccccc1

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 3/20 0.50
CHRNA7 P36544 3/20 0.50
CHRNB2 P17787 2/20 0.50
CHRNB4 P30926 2/20 0.50
CHRNA4 P43681 2/20 0.50
CHRNA1 P02708 1/20 0.47
CHRNG P07510 1/20 0.47
CHRNB1 P11230 1/20 0.47
CHRND Q07001 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7411446 0.87 CHRNA3 (0.64) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
Benzoic Acid SCHEMBL7410257 0.84 CHRNA3 (0.52) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
SCHEMBL18291207 0.78 CHRNA3 (0.67) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
Benzoic Acid SCHEMBL7411732 0.78 CHRNB2 (0.49) CHRNB2CHRNA4
Benzoic Acid SCHEMBL7829041 0.78 CHRNB2 (0.49) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
Citric Acid SCHEMBL7465133 0.72 CHRNA3 (0.49) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
Citric Acid SCHEMBL7415645 0.71 CHRNB2 (0.48) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
Citric Acid SCHEMBL7403694 0.71 CHRNB2 (0.48) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
SCHEMBL6584275 0.70 CHRNB2 (0.51) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4
SCHEMBL7913611 0.70 CHRNB2 (0.68) CHRNA3CHRNA7CHRNB2CHRNB4CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed