Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.58 |
| ▸ | MMP9 | P14780 | 17/20 | 0.58 |
| ▸ | MMP13 | P45452 | 16/20 | 0.58 |
| ▸ | MMP3 | P08254 | 13/20 | 0.58 |
| ▸ | MMP7 | P09237 | 11/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | MMP14 | P50281 | 1/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410369 | 0.86 | MMP1 (0.77) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL7761459 | 0.84 | MMP9 (0.61) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL7408927 | 0.84 | MMP9 (0.61) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL6339415 | 0.83 | MMP1 (0.76) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL6339411 | 0.83 | MMP1 (0.76) | MMP1MMP9MMP13MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL6337867 | 0.82 | MMP1 (0.74) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL6336332 | 0.82 | MMP1 (0.79) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL7375954 | 0.82 | MMP1 (0.79) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL6269894 | 0.81 | MMP9 (0.77) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL6347539 | 0.81 | MMP9 (0.77) | MMP1MMP9MMP13MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153757-A | A PRODRUG, SALT OR SOLVATE AS ANTITUMOR AGENT AND ENZYME INHIBITOR FOR INHIBITING METALLOPROTEINASES, TUMOR NECROSIS FACTOR | AGOURON PHARMACEUTICALS, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-5753653-A | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses | AGOURON PHARMACEUTICALS, INC. (US) | 1998-05-19 | — | — | US | disclosed |