Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.71 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411027 | 0.89 | CYP2C9 (0.73) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| SCHEMBL29755877 | 0.87 | KDM4E (0.85) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| SCHEMBL3067467 | 0.87 | KDM4E (0.85) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| SCHEMBL11451313 | 0.87 | CYP2C9 (0.70) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| SCHEMBL3027068 | 0.84 | CYP2C9 (0.65) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| Felodipine SCHEMBL13460298 | 0.83 | CYP2C9 (1.00) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| Felodipine SCHEMBL920025 | 0.83 | CYP2C9 (1.00) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| Felodipine SCHEMBL26398 | 0.83 | CYP2C9 (1.00) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| (R)-Felodipine SCHEMBL29617765 | 0.83 | CYP2C9 (1.00) | CYP2C9KDM4EABCB11ADORA3CYP1A2 | |
| (R)-Felodipine SCHEMBL54486 | 0.83 | CYP2C9 (1.00) | CYP2C9KDM4EABCB11ADORA3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4264611-A | HYPOTENSIVE AGENTS | AKTIEBOLAGET HASSLE (SE) | 1981-04-28 | — | — | US | claimed |
| EP-0007293-A1 | 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties, process for its preparation and pharmaceutical preparations containing it | Aktiebolaget Hässle (SE) | 1980-01-23 | — | — | EP | claimed |
| US-4264611-A | HYPOTENSIVE AGENTS | AKTIEBOLAGET HASSLE (SE) | 1981-04-28 | — | — | US | disclosed |
| EP-0007293-A1 | 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties, process for its preparation and pharmaceutical preparations containing it | Aktiebolaget Hässle (SE) | 1980-01-23 | — | — | EP | disclosed |