Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 6/20 | 0.45 |
| ▸ | MMP9 | P14780 | 5/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410503 | 0.95 | ITGB3 (0.52) | ITGB3ITGA2BL3MBTL1MMP2MMP9 | |
| Trifluoroacetic Acid SCHEMBL7415231 | 0.92 | ITGB3 (0.52) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7699204 | 0.92 | ITGB3 (0.51) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7417586 | 0.92 | ITGB3 (0.59) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| Trifluoroacetic Acid SCHEMBL7414429 | 0.91 | MMP2 (0.52) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7412625 | 0.91 | MMP2 (0.52) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7408393 | 0.91 | MMP2 (0.56) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7695353 | 0.91 | ITGB3 (0.50) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7694788 | 0.91 | MMP2 (0.56) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7416567 | 0.91 | ITGB3 (0.55) | ITGB3ITGA2BF2TMPRSS6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |