Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoquinone SCHEMBL27728283 | 0.84 | BLM (0.46) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Benzoquinone SCHEMBL27348089 | 0.84 | FFAR3 (0.65) | ALDH1A1MAPK1BCHEPOLBMAOA | |
| Benzoquinone SCHEMBL31055608 | 0.79 | ALDH1A1 (0.67) | ALDH1A1MAPK1BCHEPOLBMAOA | |
| Benzoquinone SCHEMBL27519977 | 0.79 | ALDH1A1 (0.67) | ALDH1A1MAPK1BCHEPOLBMAOA | |
| Benzoquinone SCHEMBL28211057 | 0.79 | TDP1 (0.80) | ALDH1A1MAPK1BCHEPOLBMAOA | |
| Benzoquinone SCHEMBL8966070 | 0.79 | TDP1 (0.80) | ALDH1A1MAPK1BCHEPOLBMAOA | |
| Benzoquinone SCHEMBL10412922 | 0.79 | GLRA1 (0.59) | LMNAALDH1A1MAPK1BCHEPOLB | |
| Benzoquinone SCHEMBL3738782 | 0.79 | FFAR3 (0.59) | LMNAALDH1A1MAPK1BCHEPOLB | |
| Benzoquinone SCHEMBL11704087 | 0.79 | TDP1 (0.47) | ALDH1A1MAPK1BCHEPOLBMAOA | |
| Succinic Acid SCHEMBL4739951 | 0.75 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133322-A | TREATING OR PREVENTING A DISORDER RESULTING FROM A MITOCHONDRIAL DYSFUNCTION INDUCED BY AN IRON OVERLOAD COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF AN UBIQUINONE DERIVATIVE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-17 | — | — | US | disclosed |