Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.73 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.73 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.73 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.73 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.73 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.73 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414235 | 0.92 | CHRNA3 (0.70) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL905222 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL7365529 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL8438283 | 0.83 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7828342 | 0.83 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL905227 | 0.83 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7840224 | 0.83 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL7408572 | 0.83 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7461082 | 0.82 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7455078 | 0.82 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |