Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | CHUK | O15111 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227532 | 0.82 | NAPRT (0.53) | NAPRTALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL8469600 | 0.78 | PDPK1 (0.43) | PDPK1NAPRTTYK2TDP1BTK | |
| SCHEMBL16043412 | 0.77 | — | — | |
| SCHEMBL7431725 | 0.76 | PDPK1 (0.42) | PDPK1NAPRTTYK2BTKIKBKB | |
| SCHEMBL7413081 | 0.76 | PDPK1 (0.39) | PDPK1NAPRTTYK2BTKIKBKB | |
| SCHEMBL25487757 | 0.74 | NAPRT (0.33) | NAPRTALDH1A1PARP1KDM4EHPGD | |
| SCHEMBL14848174 | 0.74 | NAPRT (0.33) | NAPRTALDH1A1PARP1KDM4EHPGD | |
| SCHEMBL6219929 | 0.74 | ALDH1A1 (0.56) | ALDH1A1MAPTKDM4EHPGDNUDT1 | |
| SCHEMBL18585161 | 0.73 | TYK2 (0.39) | PDPK1NAPRTTYK2BTKALDH1A1 | |
| SCHEMBL12970665 | 0.73 | PDPK1 (0.37) | PDPK1NAPRTTYK2IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045845-A1 | N-OXIDES OF HETEROCYCLIC COMPOUNDS WITH TNF AND PDE-IV INHIBITING ACTIVITY | Darwin Discovery Limited (GB) | 2000-10-25 | — | — | EP | claimed |
| WO-2000026208-A1 | N-OXIDES OF HETEROCYCLIC COMPOUNDS WITH TNF AND PDE-IV INHIBITING ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 2000-05-11 | — | — | WO | claimed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| EP-1054884-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999040085-A1 | BENZOFURAN-4-CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1999-08-12 | — | — | WO | disclosed |