Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741499 | 0.77 | TSHR (0.44) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL740027 | 0.75 | CES1 (0.45) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL27457467 | 0.74 | CES1 (0.44) | CES1TDP1L3MBTL1LMNACES2 | |
| SCHEMBL31423404 | 0.74 | MAPT (0.44) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL6341233 | 0.74 | CES1 (0.44) | CES1TDP1L3MBTL1LMNACES2 | |
| SCHEMBL740969 | 0.71 | TDP1 (0.47) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL29237750 | 0.71 | TDP1 (0.47) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL23091851 | 0.70 | TDP1 (0.50) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL408412 | 0.70 | TDP1 (0.50) | CES1TDP1L3MBTL1LMNAHPGD | |
| SCHEMBL28250455 | 0.70 | LMNA (0.39) | CES1TDP1L3MBTL1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130842-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-11-18 | — | — | WO | disclosed |