Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094960 | 0.77 | KDM4E (0.37) | SMN1; SMN2KDM4EPOLBALDH1A1RAB9A | |
| SCHEMBL6350872 | 0.65 | KAT2B (0.38) | SMN1; SMN2KDM4EPOLBALDH1A1PPARG | |
| SCHEMBL6350869 | 0.65 | KAT2B (0.38) | SMN1; SMN2KDM4EPOLBALDH1A1PPARG | |
| SCHEMBL6422034 | 0.64 | KAT2B (0.40) | SMN1; SMN2KDM4EALDH1A1PPARGKAT2B | |
| SCHEMBL6350953 | 0.62 | KAT2B (0.35) | MAPTSMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL6347799 | 0.61 | PPARG (0.37) | SMN1; SMN2KDM4EHTTPPARGKAT2B | |
| SCHEMBL6351322 | 0.60 | PPARG (0.36) | SMN1; SMN2KDM4EHTTPPARGKAT2B | |
| SCHEMBL5163732 | 0.59 | GSK3A (0.66) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL14086671 | 0.58 | PPARG (0.44) | SMN1; SMN2KDM4EPOLBHTTALDH1A1 | |
| SCHEMBL24438687 | 0.56 | ALDH1A1 (0.49) | MAPTSMN1; SMN2KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815084-A1 | LACTAM-CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEASE | THE PROCTER & GAMBLE COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5672598-A | MATRIX METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1996029313-A1 | LACTAM-CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEASE | THE PROCTER & GAMBLE COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |