Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418067 | 0.83 | LMNA (0.49) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7416005 | 0.77 | HTT (0.44) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7422019 | 0.74 | LMNA (0.53) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| Benzyl Phenethylcarbamate SCHEMBL4287199 | 0.69 | LMNA (0.73) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13055383 | 0.68 | LMNA (0.80) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5019074 | 0.67 | LMNA (0.73) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| Benzyl Phenethylcarbamate SCHEMBL6392045 | 0.66 | LMNA (0.67) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4506331 | 0.66 | LMNA (0.71) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL127662 | 0.66 | HTT (0.82) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1051884 | 0.66 | LMNA (0.71) | HTTLMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438118-A | Peptide mimics having constrained peptide backbone | SMITHKLINE BEECHMAN CORP. (US) | 1995-08-01 | — | — | US | disclosed |
| WO-1992009297-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |