Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.57 |
| ▸ | MMP9 | P14780 | 10/20 | 0.57 |
| ▸ | MMP13 | P45452 | 9/20 | 0.57 |
| ▸ | MMP1 | P03956 | 8/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422810 | 0.85 | KMT2A (0.41) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL7418210 | 0.84 | ADAM17 (0.57) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3937334 | 0.82 | ADAM17 (0.64) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3939497 | 0.81 | ADAM17 (0.74) | ADAM17MMP9MMP13MMP1MMP14 | |
| SCHEMBL3948475 | 0.80 | ADAM17 (0.61) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL7414426 | 0.79 | ADAM17 (0.58) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3948040 | 0.78 | ADAM17 (0.65) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6655712 | 0.78 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3946154 | 0.78 | ADAM17 (0.69) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL3948467 | 0.77 | ADAM17 (0.57) | ADAM17MMP9MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | claimed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |