Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.57 |
| ▸ | MMP9 | P14780 | 8/20 | 0.57 |
| ▸ | MMP13 | P45452 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 5/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414307 | 0.84 | ADAM17 (0.57) | ADAM17MMP9MMP13KMT2AMEN1 | |
| SCHEMBL7422810 | 0.84 | KMT2A (0.41) | ADAM17MMP9MMP13KMT2AMEN1 | |
| SCHEMBL3939996 | 0.82 | ADAM17 (0.63) | ADAM17MMP9MMP13ALDH1A1MMP1 | |
| SCHEMBL3940241 | 0.80 | ADAM17 (0.73) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3945185 | 0.79 | ADAM17 (0.59) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL7415917 | 0.78 | ADAM17 (0.58) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL4202703 | 0.78 | ADAM17 (0.55) | ADAM17MMP9MMP13MAPTMMP1 | |
| SCHEMBL7466803 | 0.78 | ADAM17 (0.59) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL7414772 | 0.78 | ADAM17 (0.57) | ADAM17MMP9MMP13KMT2AMEN1 | |
| SCHEMBL3944998 | 0.77 | ADAM17 (0.68) | ADAM17MMP9MMP13ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | claimed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |