Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742271 | 0.76 | REN (0.44) | REN | |
| SCHEMBL10183100 | 0.60 | HPGD (0.41) | — | |
| SCHEMBL1864543 | 0.56 | CHRM3 (0.38) | REN | |
| SCHEMBL3593760 | 0.56 | CHRM3 (0.38) | REN | |
| SCHEMBL1864547 | 0.56 | CHRM3 (0.38) | REN | |
| SCHEMBL21193077 | 0.56 | PIM1 (0.34) | PIM1PIM3PIM2 | |
| SCHEMBL741588 | 0.56 | QPCT (0.34) | — | |
| SCHEMBL19512235 | 0.56 | CCR9 (0.39) | — | |
| SCHEMBL8959911 | 0.55 | OPRM1 (0.43) | — | |
| SCHEMBL20112460 | 0.54 | CNR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |