Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414659 | 0.78 | CHRM4 (0.40) | L3MBTL1CYP2C9CYP2C19HTR2BMAPK14 | |
| SCHEMBL7415999 | 0.74 | CTSK (0.45) | — | |
| SCHEMBL7416005 | 0.73 | HTT (0.44) | L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL7413750 | 0.72 | ACE (0.39) | DDB1CRBN | |
| SCHEMBL2763746 | 0.69 | TP53 (0.38) | L3MBTL1TP53FFAR1PPARDMAPT | |
| SCHEMBL10780374 | 0.65 | AKR1C4 (0.35) | FFAR1PPARDLMNAMAPTSMN1; SMN2 | |
| SCHEMBL10642729 | 0.63 | TP53 (0.56) | L3MBTL1TP53FFAR1KDM4EMAPT | |
| SCHEMBL29016897 | 0.63 | DDB1 (0.61) | DDB1CRBNCYP19A1 | |
| SCHEMBL10774081 | 0.62 | OAT (0.34) | L3MBTL1TP53FFAR1LMNAMAPT | |
| SCHEMBL27657157 | 0.62 | DDB1 (0.55) | DDB1CRBNCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438118-A | Peptide mimics having constrained peptide backbone | SMITHKLINE BEECHMAN CORP. (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0559793-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0559793-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009297-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |