Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382377 | 0.79 | SIRT3 (0.33) | HTTTDP1 | |
| SCHEMBL7379834 | 0.74 | CYP2C19 (0.37) | HTTTDP1L3MBTL1 | |
| SCHEMBL7377175 | 0.68 | HTT (0.46) | HTTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL7415558 | 0.67 | TSHR (0.40) | KDM4ETDP1L3MBTL1 | |
| SCHEMBL7562318 | 0.67 | PARP1 (0.46) | TDP1L3MBTL1 | |
| SCHEMBL7379785 | 0.66 | TNF (0.40) | L3MBTL1 | |
| SCHEMBL7417041 | 0.66 | GAA (0.37) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL7377241 | 0.65 | NPC1 (0.43) | HTTMEN1KMT2A | |
| SCHEMBL7412862 | 0.65 | KDM4E (0.42) | HTTKDM4E | |
| SCHEMBL7384414 | 0.64 | ICAM1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |