Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | USP8 | P40818 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381164 | 0.79 | ALDH1A1 (0.39) | TSHRALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL12251164 | 0.69 | TSHR (0.56) | TSHRALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL29045412 | 0.68 | DPP4 (0.41) | TSHRCTSAALDH1A1KDM4EMAPT | |
| SCHEMBL7414697 | 0.67 | HTT (0.31) | KDM4EL3MBTL1TDP1 | |
| SCHEMBL7382377 | 0.67 | SIRT3 (0.33) | TDP1 | |
| SCHEMBL7415556 | 0.67 | TSHR (0.41) | TSHRCTSASLC9A1ALDH1A1GAA | |
| SCHEMBL12490635 | 0.66 | TSHR (0.52) | TSHRALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL7562318 | 0.66 | PARP1 (0.46) | CTSAGAAL3MBTL1TDP1 | |
| SCHEMBL29740378 | 0.65 | LRRK2 (0.46) | ALDH1A1L3MBTL1LMNANPC1 | |
| SCHEMBL25594818 | 0.65 | TSHR (0.39) | TSHRSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |