Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411450 | 0.87 | PARP1 (0.39) | PARP1HRH4 | |
| SCHEMBL6873048 | 0.82 | PARP1 (0.47) | PARP1HRH4 | |
| SCHEMBL6874969 | 0.77 | PARP1 (0.51) | PARP1HRH4 | |
| SCHEMBL5621000 | 0.76 | PARP1 (0.68) | PARP1 | |
| SCHEMBL7411210 | 0.75 | PARP1 (0.37) | PARP1 | |
| SCHEMBL7410126 | 0.74 | NPY5R (0.44) | PARP1NPC1RAB9AHRH4 | |
| SCHEMBL7415578 | 0.74 | PIM1 (0.40) | PARP1HRH4 | |
| SCHEMBL7408313 | 0.74 | NPC1 (0.52) | PARP1NPC1RAB9AHRH4 | |
| SCHEMBL7417446 | 0.73 | HTR3A (0.40) | PARP1 | |
| SCHEMBL6314907 | 0.72 | PARP1 (0.36) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |