Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403474 | 0.88 | CYP11B2 (0.44) | CYP11B2NOTUMPOLB | |
| SCHEMBL21792321 | 0.72 | CYP11B2 (0.54) | CYP11B2NOTUMLMNAPOLBRXFP1 | |
| SCHEMBL20939398 | 0.71 | CYP11B2 (0.48) | CYP11B2NOTUM | |
| SCHEMBL20939587 | 0.69 | NOTUM (0.46) | CYP11B2NOTUM | |
| SCHEMBL6275623 | 0.68 | MEN1 (0.41) | NOTUMSMN1; SMN2 | |
| SCHEMBL7415790 | 0.68 | PARP1 (0.43) | GAAHPGDPOLBGALK1 | |
| SCHEMBL20939323 | 0.66 | NOTUM (0.56) | CYP11B2NOTUM | |
| SCHEMBL28834876 | 0.66 | NOTUM (0.65) | NOTUMHPGDLMNAPOLBSMN1; SMN2 | |
| SCHEMBL23604609 | 0.65 | GAA (0.49) | GAAHPGDLMNAPOLBGALK1 | |
| SCHEMBL6771563 | 0.65 | KDM4E (0.58) | GAAHPGDPOLBGALK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5063230-A | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-11-05 | — | — | US | disclosed |
| WO-1990006113-A1 | SUBSTITUTED SATURATED AND UNSATURATED INDOLE QUINOLINE AND BENZAZEPINE CARBOXAMIDES AND THEIR USE AS PHARMACOLOGICAL AGENTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| US-4920219-A | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |