Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.63 |
| ▸ | PDE4A | P27815 | 4/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bemoradan SCHEMBL121664 | 0.78 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Bemoradan SCHEMBL29605229 | 0.78 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7343945 | 0.77 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7410994 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11323239 | 0.72 | PDE3B (0.69) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10353457 | 0.71 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10902917 | 0.71 | PDE3B (0.79) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7349435 | 0.71 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10902870 | 0.70 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7341030 | 0.70 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515668-A4 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO 4,3-B)-1,4-BENZOXAZINES | — | 1993-03-10 | — | — | EP | claimed |
| EP-0515668-A1 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO 4,3-b]-1,4-BENZOXAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-12-02 | — | — | EP | claimed |
| WO-1992011265-A1 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO[4,3-b]-1,4-BENZOXAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | claimed |
| EP-0515668-A4 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO 4,3-B)-1,4-BENZOXAZINES | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0515668-A1 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO 4,3-b]-1,4-BENZOXAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-12-02 | — | — | EP | disclosed |
| WO-1992011265-A1 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO[4,3-b]-1,4-BENZOXAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | disclosed |
| US-5116837-A | 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |