SCHEMBL7415007

SCHEMBL7415007

O=C(OCc1ccccc1)C(Oc1cccnc1F)[C@@H]1CCN1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.40
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.37
GRIN2B Q13224 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
TSHR P16473 1/20 0.36
CASP3 P42574 1/20 0.36
RAB9A P51151 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
PPIA P62937 2/20 0.35
ITGB3 P05106 1/20 0.35
ITGA2B P08514 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
HTR1A P08908 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7406938 0.85 GLA (0.38) GLAKMT2AGRIN2BTSHRRAB9A
SCHEMBL7405289 0.83 GLA (0.36) GLAGRIN2BTSHRCYP3A4CYP2C9
SCHEMBL7411868 0.83 GLA (0.36) GLAGRIN2BTSHRCYP3A4CYP2C9
SCHEMBL7411933 0.79 CYP3A4 (0.38) GLAL3MBTL1TSHRITGB3ITGA2B
SCHEMBL7414234 0.79 CYP3A4 (0.38) GLAL3MBTL1TSHRITGB3ITGA2B
SCHEMBL7410510 0.78 TSHR (0.35) GLAL3MBTL1TSHRCYP3A4CYP2C9
SCHEMBL7414435 0.78 TSHR (0.35) GLAL3MBTL1TSHRCYP3A4CYP2C9
SCHEMBL7414580 0.77 TSHR (0.35) GLAKMT2AL3MBTL1TSHRCYP3A4
SCHEMBL8418050 0.74 SRC (0.40) GLATSHRCYP3A4CYP2C9CYP2C19
SCHEMBL7414311 0.73 MEN1 (0.45) KMT2AGRIN2BTSHRCYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
EP-0950057-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS Abbott Laboratories (US) 1999-10-20 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed
WO-1998025920-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LABORATORIES (US) 1998-06-18 WO disclosed
EP-0846114-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-06-10 EP disclosed
WO-1996040682-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1996-12-19 WO disclosed