Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410510 | 0.89 | TSHR (0.35) | TSHRHTR2CSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7414435 | 0.89 | TSHR (0.35) | TSHRHTR2CSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7411933 | 0.83 | CYP3A4 (0.38) | TSHRHTR2CLMNAL3MBTL1CYP3A4 | |
| SCHEMBL7414234 | 0.83 | CYP3A4 (0.38) | TSHRHTR2CLMNAL3MBTL1CYP3A4 | |
| SCHEMBL7414311 | 0.79 | MEN1 (0.45) | TSHRHTR2CMEN1KMT2ACYP3A4 | |
| SCHEMBL7414092 | 0.79 | MEN1 (0.45) | TSHRHTR2CMEN1KMT2ACYP3A4 | |
| SCHEMBL7415007 | 0.77 | GLA (0.40) | TSHRSLC6A2SLC6A3SLC6A4L3MBTL1 | |
| SCHEMBL7405289 | 0.75 | GLA (0.36) | TSHRHTR2CSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7411868 | 0.75 | GLA (0.36) | TSHRHTR2CSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7411997 | 0.75 | YAP1 (0.40) | HTR2CLMNAL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |