Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.49 |
| ▸ | PDE4A | P27815 | 11/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937749 | 0.92 | TPH1 (0.51) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7412528 | 0.88 | TPH1 (0.47) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7471407 | 0.84 | PDE4B (0.50) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2467226 | 0.83 | RECQL (0.53) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7418284 | 0.81 | RECQL (0.47) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL19389980 | 0.81 | TPH1 (0.41) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7422273 | 0.80 | RECQL (0.47) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7937862 | 0.77 | RECQL (0.52) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7088472 | 0.76 | PDE4B (0.65) | TPH1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7940449 | 0.75 | RECQL (0.55) | TPH1PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922751-A | BRONCHODILATOR AND ANTIINFLAMMATORY AGENT WITHOUT UNDESIRABLE CARDIOVASCULAR STIMULATION CAUSED BY PHOSPHODIESTERASE III INHIBITOR | EURO-CELTIQUE, S.A. (LU) | 1999-07-13 | — | — | US | claimed |
| EP-0766676-B1 | COMPOUNDS FOR INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 2002-05-22 | — | — | EP | disclosed |
| US-6248769-B1 | ANTIINFLAMMATORY AGENT | EURO-CELTIQUE S.A. (LU) | 2001-06-19 | — | — | US | disclosed |
| US-6103749-A | PHENYL IMIDAZOLE COMPOUNDS USEFUL FOR TREATMENT OF ASTHMA, ALLERGIES, INFLAMMATION AND DEPRESSION | EURO-CELTIQUE S.A. (LU) | 2000-08-15 | — | — | US | disclosed |
| US-5922751-A | BRONCHODILATOR AND ANTIINFLAMMATORY AGENT WITHOUT UNDESIRABLE CARDIOVASCULAR STIMULATION CAUSED BY PHOSPHODIESTERASE III INHIBITOR | EURO-CELTIQUE, S.A. (LU) | 1999-07-13 | — | — | US | disclosed |
| EP-0766676-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-07-08 | — | — | EP | disclosed |
| EP-0766676-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-04-09 | — | — | EP | disclosed |
| WO-1996000218-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-01-04 | — | — | WO | disclosed |