SCHEMBL7415822

SCHEMBL7415822

C[C@@]1(COc2cncc(C(=O)O)c2)CCCN1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
HTT P42858 1/20 0.40
GFER P55789 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HCAR2 Q8TDS4 4/20 0.37
NR1H4 Q96RI1 1/20 0.36
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 3/20 0.35
POLB P06746 1/20 0.34
LMNA P02545 1/20 0.34
DDO Q99489 1/20 0.34
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33
P2RX3 P56373 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23501708 0.82 MEN1 (0.47) MEN1KMT2AHTTGFERHSD17B10
SCHEMBL29934049 0.82 MEN1 (0.47) MEN1KMT2AHTTGFERHSD17B10
SCHEMBL7407387 0.81 CHRNB2 (0.43) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7581749 0.80 CHRNB2 (0.52) CHRNB4CHRNA3CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL7411065 0.80 CHRNB2 (0.42) CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL7411005 0.76 CHRNB2 (0.36) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7412587 0.75 CHRNB2 (0.42) CHRNB2CHRNA4
SCHEMBL31287046 0.73 NR1H4 (0.44) MEN1KMT2AHTTGFERHSD17B10
SCHEMBL6657708 0.73 CHRNB2 (0.51) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL3637078 0.72 CYP2D6 (0.38) MEN1KMT2AGFERHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed