SCHEMBL7407387

SCHEMBL7407387

C[C@@]1(COc2cncc(Br)c2)CCCN1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.43
CHRNA4 P43681 4/20 0.43
TACR1 P25103 1/20 0.34
SLC6A4 P31645 1/20 0.34
KCNH2 Q12809 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7411065 0.99 CHRNB2 (0.42) CHRNB2CHRNA4TACR1SLC6A4KCNH2
SCHEMBL7412587 0.94 CHRNB2 (0.42) CHRNB2CHRNA4TACR1SLC6A4KCNH2
SCHEMBL7581749 0.85 CHRNB2 (0.52) CHRNB2CHRNA4CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL7411005 0.81 CHRNB2 (0.36) CHRNB2CHRNA4TACR1CHRNB4CHRNA3
SCHEMBL7415822 0.81 MEN1 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL6657708 0.78 CHRNB2 (0.51) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7408578 0.78 CHRNB2 (0.41) CHRNB2CHRNA4
SCHEMBL8587245 0.76 CHRNB2 (0.38) CHRNB2CHRNA4TACR1SLC6A4KCNH2
Hydrochloric Acid SCHEMBL7413367 0.75 CHRNB2 (0.39) CHRNB2CHRNA4TACR1SLC6A4KCNH2
SCHEMBL1622035 0.73 CHRNB2 (0.43) CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
EP-0934308-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1999-08-11 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed
WO-1997046554-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-12-11 WO disclosed