Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1611151 | 0.79 | TP53 (0.58) | TP53TDP1NPC1CASP3SENP8 | |
| SCHEMBL11520449 | 0.78 | LCK (0.47) | LMNASMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL3338836 | 0.76 | ALDH1A1 (0.42) | LMNACYP3A4MAPTMAOBALDH1A1 | |
| SCHEMBL3106109 | 0.75 | TP53 (0.54) | TP53TDP1NPC1CASP3SENP8 | |
| SCHEMBL27258520 | 0.75 | TP53 (0.54) | TP53TDP1NPC1CASP3SENP8 | |
| SCHEMBL8097032 | 0.72 | TP53 (0.50) | TP53TDP1NPC1CASP3SENP8 | |
| SCHEMBL1609607 | 0.72 | TP53 (0.50) | TP53TDP1NPC1CASP3SENP8 | |
| SCHEMBL29456572 | 0.72 | — | — | |
| SCHEMBL7227961 | 0.72 | TP53 (0.60) | TP53TDP1NPC1CASP3SENP8 | |
| SCHEMBL65797 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071528-A1 | 4H-1,4-BENZOTHIAZINE-2-CARBOXAMIDES AND THEIR USE AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-11-30 | — | — | WO | disclosed |