Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616774 | 0.79 | LCK (0.54) | LCKABL1BCRTSHRCCNB2 | |
| SCHEMBL7415952 | 0.78 | TP53 (0.50) | LMNASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL5644855 | 0.76 | LCK (0.50) | LCKABL1BCRTSHRCCNB2 | |
| SCHEMBL28099212 | 0.75 | LCK (0.54) | LCKABL1BCRCCNB2CDK1 | |
| SCHEMBL11564725 | 0.75 | CYP3A4 (0.50) | RAB9ALMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3338836 | 0.74 | ALDH1A1 (0.42) | TSHRLMNAKDM4EALDH1A1CYP3A4 | |
| SCHEMBL4536567 | 0.74 | KDM4E (0.52) | LCKHIF1ATSHRNFKB1RAB9A | |
| SCHEMBL28292226 | 0.74 | LCK (0.52) | LCKABL1BCRTSHRCCNB2 | |
| SCHEMBL7564693 | 0.73 | LCK (0.47) | LCKABL1BCRTSHRCCNB2 | |
| SCHEMBL19669791 | 0.73 | KDM4E (0.44) | LCKHIF1AABL1BCRADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4174450-A | Intermediates useful in the preparation of optically and therapeutically active-m-acyloxy-(methyl-amino) methyl benzyl alcohols | INTERX RESEARCH CORPORATION (US) | 1979-11-13 | — | — | US | disclosed |
| US-4158005-A | Intermediates useful in the synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols | INTERX RESEARCH CORPORATION (US) | 1979-06-12 | — | — | US | disclosed |
| US-4088783-A | Novel optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols and the pharmaceutically acceptable acid addition salts thereof | INTERX RESEARCH CORPORATION (US) | 1978-05-09 | — | — | US | disclosed |
| US-4028368-A | Novel intermediates useful in the synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols | INTERX RESEARCH CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-3966749-A | Novel synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof | INTERX RESEARCH CORPORATION (US) | 1976-06-29 | — | — | US | disclosed |