Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28884912 | 0.82 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL29150713 | 0.80 | TACR1 (0.40) | TACR1NPC1JAK2RAB9APAX8 | |
| SCHEMBL10731691 | 0.77 | SLC6A2 (0.44) | TACR1SIGMAR1CHRM2CHRM1CHRM3 | |
| Piperazine SCHEMBL28177083 | 0.74 | MEN1 (0.48) | SIGMAR1 | |
| SCHEMBL4936112 | 0.72 | SIGMAR1 (0.39) | SIGMAR1 | |
| SCHEMBL21590186 | 0.71 | MC4R (0.44) | SIGMAR1CHRM2CHRM1CHRM3 | |
| SCHEMBL720769 | 0.70 | NPC1 (0.50) | TACR1NPC1JAK2RAB9APAX8 | |
| SCHEMBL27489076 | 0.70 | LMNA (0.40) | NPC1RAB9ASIGMAR1 | |
| SCHEMBL4421969 | 0.70 | TACR1 (0.53) | TACR1NPC1JAK2RAB9APAX8 | |
| SCHEMBL2249240 | 0.70 | SIGMAR1 (0.42) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069143-A | Fibrinogen receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0885213-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0885213-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997025323-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |